In addition, patients with diffuse lesion had significantly higher levels of NSE (32.36 ± 23.78 vs. 12.94 ± 6.17 ng/mL, p < 0.001), which was not associated with ILD (28.78 ± 23.14 vs. 19.32 ± 16.18 ng/mL, p = 0.141) or cancer (42.00 ± 29.70 vs. 23.13 ± 19.58 ng/mL, p = 0.072). This evidence concerns the gene ENO2 and cancer.