LCAT was enriched for a total of 74 functional pathways, of which the top 10 results were ribosome, oxidative phosphorylation, Parkinson’s disease, pathways in cancer, Huntington’s disease, Jak–STAT signaling pathway, T cell receptor signaling pathway, apoptosis, chemokine signaling pathway and ubiquitin mediated proteolysis (p < 0.05) (Figure 5C; Supplementary Table 8). Here, SOAT1 is linked to juvenile Huntington disease.