TAFAZZIN and early-infantile DEE: Non-isolated LVNC phenotypes with extended clinical variability in youngchildren have been associated with mitochondrial disorders, such as Barthsyndrome, which is caused by TAZ/G4.5 (tafazzin) mutations,zaspopathy-caused mutations in ZASP, hereditary neuromuscular disorders,chromosomal defects (such as 1p36, 1q43, and distal 5q deletions), Turnersyndrome, Ohtahara syndrome, trisomy 22, trisomy 13, and DiGeorge syndrome [6, 9, 18, 65, 82, 83, 84].