SLC5A2 and hydrops fetalis: However, significant progresshas recently been made in the pharmacologic treatment of HF, especially with theintroduction of the sodium–glucose cotransporter 2 (SGLT2) inhibitor (SGLT2i),which has transformed the therapeutic regimen of HF from the traditional “GoldenTriangle” to the “New Quadruple Therapy”, and has greatly reduced thereadmission and mortality rates of HF patients.