In a mousemodel of HF, when HF occurred, AMPKα2 expression and activitywere elevated five days after TAC, but decreased fourteen days after TAC [22].The expression and activity of AMPKα2 were consistent with thelevel of mitophagy in cardiac tissues of mice with HF, and its downregulation ledto impaired mitophagy and exacerbated HF. Here, PRKAA2 is linked to hydrops fetalis.