Further studies have revealed thatAMPKα2 overexpression phosphorylates the Ser495 site inPTEN-induced putative kinase 1 (PINK1), activates the PINK1/E3 ubiquitin-proteinligase Parkin/Sequestosome 1 pathway, and increases the level of mitophagy inearly HF [22]. The gene discussed is PINK1; the disease is hydrops fetalis.