DPP4 and hydrops fetalis: For example, Rodriguez-Valadez et al. [95] analyzed asystematic review that included 9 GLP-1RA’s trials and 13 SGLT2i trials,confirming that the reduction in HbA1c by GLP-1RAs may increase the risk of MACE.Moreover, compared with DPP-4 inhibitors and SGLT2 inhibitors, GLP-1RAssignificantly reduced hospitalization rates in patients with HF [96].