EXA administration in control rats did not produce significant changes. TAA induced cirrhosis with notable changes in insulin resistance and cardiac function. GLP-1R, HOTAIR, and SIRT1 expression in cardiac tissue were significantly reduced, while troponin I levels were markedly elevated. The TAA + EXA group showed recovery of liver structure and function. EXA treatment significantly improved cardiac parameters, which were associated with increased expression of cardiac GLP-1R and HOTAIR. Here, SIRT1 is linked to Cirrhosis.