GLP1R and cardiomyopathy: Glp1r-⁣/- hearts exhibited chamber-specific differences in gene expression but showed normal mortality and LV remodeling following MI or experimental doxorubicin-induced cardiomyopathy. GLP-1RAs like liraglutide demonstrated strong cardioprotective effects and improved survival rates in Glp1rCM-⁣/- mice even after LAD coronary artery ligation. Although liraglutide increased HR in Glp1rCM-⁣/- mice, these mice exhibited significantly lower baseline HR compared to controls.