The molecular mechanisms of CKM diseases include a series of interconnected factors, such as hyperglycemia, insulin resistance, the renin‐angiotensin‐aldosterone system, advanced glycation end products, oxidative stress, lipotoxicity, endoplasmic reticulum stress, calcium handling abnormalities, mitochondrial dysfunction, impaired energy production, and chronic persistent inflammation (Sebastian et al. 2024). The gene discussed is REN; the disease is Insulin resistance.