The in vitro evidence demonstrates that curcumin exerts significant cytotoxic effects on CML cell lines, primarily through the induction of apoptosis, cell cycle arrest, autophagy, and the disruption of key oncogenic signaling pathways, including BCR‐ABL1, PKCα, WT1, and HDAC8. Here, HDAC8 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.