Zhuo Yu et al. found that bufalin inhibits PLC5 HCC cell proliferation, transformation, and cell cycle progression, but not LO2 cells, which is related to CCRK-mediated β-catenin/TCF signalling (Yu et al., 2018), Molecular docking experiments remain warranted to further validate the underlying molecular mechanisms. Here, HNF4A is linked to hepatocellular carcinoma.