CCND1 and hepatocellular carcinoma: Further studies have found that sempervirine can significantly inhibit the nuclear aggregation level of β-catenin and inhibit the transcriptional level of the Wnt pathway, which in turn downregulates its downstream genes cyclin D1, cyclin B1 and CDK2, blocks the G1 phase of the cell cycle and ultimately induces apoptosis in HCC cells (In vivo, Mice, i.