Recent studies found that KXRGG markedly diminishes the expression of Wnt1, β-catenin, Cyclin D1, c-Myc, MMP-7, Axin-2, and EpCAM proteins, inhibits the conversion of HOCs into HCC cells, and offers novel insights into the anti-fibrosis-HCC mechanism of drugs via the Wnt/β-catenin signalling pathway (Tang W. et al., 2022). The gene discussed is AXIN2; the disease is hepatocellular carcinoma.