Concurrent studies find that CKI suppresses c-Myc expression by modulating the Wnt/β-catenin signalling pathway, affecting metabolic reprogramming and EMT in HCC, therefore hindering the invasion and metastasis of SMMC-7721 cells (In vivo, Mice, p. o., 1.5–3 mL/kg, 3 weeks, 5-FU (positive control)) (Wang K. X. et al., 2021). The gene discussed is MYC; the disease is hepatocellular carcinoma.