CCL2 and bone inflammation disease: In addition, SCSP modulates inflammatory cascades by attenuating IL-17 signaling (Byravan et al., 2024; Peng et al., 2024), Toll-like receptor pathways (Carroll et al., 2025; He et al., 2016), and key genes implicated in inflammatory bone diseases (Lo et al., 2024), such as Ccl2, Il17re, Fosl1, Mmp13, Ccl5, Tlr1, Il12b, and Atp6v1b1.