In addition, SCSP modulates inflammatory cascades by attenuating IL-17 signaling (Byravan et al., 2024; Peng et al., 2024), Toll-like receptor pathways (Carroll et al., 2025; He et al., 2016), and key genes implicated in inflammatory bone diseases (Lo et al., 2024), such as Ccl2, Il17re, Fosl1, Mmp13, Ccl5, Tlr1, Il12b, and Atp6v1b1. Here, CCL5 is linked to bone inflammation disease.