PPARG and diabetes mellitus: Wenxiang Hu et al. used human adipose stem cell-derived adipocytes to demonstrate that the specific single nucleotide polymorphism rs4743771 could regulate the PPARγ target gene ABCA1, and that single nucleotide polymorphisms were enriched in the patient-specific PPARγ binding site, which correlates with the individual-specific effect of the azolidinediones drug rosiglitazone, explaining the inefficacy of this type of drug in some patients with diabetes(Nanjan et al., 2018; Hu et al., 2019).