Xiaoping Yang and colleagues found that bile acid receptor agonists could reverse TGF-β1-induced renal fibrosis by regulating the Farnesoid X receptor, p-SMAD3, and TAZ in iPSC-derived renal organoids, demonstrating that bile acid receptor agonism exists in the early stage of renal fibrosis (Yang et al., 2024). Here, SMAD3 is linked to renal fibrosis.