ACE2 and diabetes mellitus: Xia Y et al. established a diabetes-like renal organoid using alternating 5 mM and 25 mM glucose every 24 h to mimic glucose level shocks in patients with diabetes and found that diabetic-like renal organoids and patients with diabetes had higher angiotensin-converting enzyme 2 (ACE2) expression levels (Xia et al., 2022).