MAPT and Cognitive impairment: Few studies have investigated circadian rhythms with respect to Aβ and tau neuropathology in early Alzheimer’s states, such as preclinical and MCI populations.25,68-70 To our knowledge, this is the first study to investigate the associations between circadian rhythms and pathological hallmarks (Aβ and tau) as well as cognition in older adults with objective early cognitive impairment.