Using a tau transgenic mouse model, they found that circadian regulation by the core clock gene Bmal1 modulated the oscillation of a chaperone protein called Hsp70, which plays a crucial role in tau metabolism.95 A different study using a mouse model of Alzheimer’s disease demonstrated that melatonin administration reduced expression levels of phosphorylated tau,96 introducing circadian therapy as a viable possibility for the attenuation of Alzheimer’s-related tau neuropathology. The gene discussed is CLOCK; the disease is early-onset autosomal dominant Alzheimer disease.