Anti-diabetic medications, especially insulin and insulin secretagogues such as sulfonylureas, often result in hypoglycemia in people with type 2 diabetes [5,6]. In addition to interfering with day-to-day tasks, it may cause serious morbidity, such as seizures, cognitive decline, cardiovascular events, and even death [7]. Frequent hypoglycemia episodes may cause hypoglycemia unawareness, which raises the danger of potentially fatal situations by impairing the body's normal counterregulatory reactions [8]. The gene discussed is INS; the disease is type 2 diabetes mellitus.