PRKCA and Hyperglycemia: Here, it is also important to highlight Dang et al., who tested both PKCβ and PKCα inhibition, and surprisingly found that PKCα inhibition with hypocrellin A had an even more pronounced effect on attenuating hyperglycemia-induced endothelial hyperpermeability in their human umbilical vein endothelial cell model than PKCβ inhibition (61).