Furthermore, conditioned medium of bovine aortic endothelial cells enhanced vascular smooth muscle Na/K pump activity to a far greater degree in spontaneously hypertensive rats than normotensive controls, with the effect reduced following treatment with PKC inhibitor staurosporine, pointing to a role for PKC in enhanced endothelium-dependent microvascular responses in hypertension (143). This evidence concerns the gene PRRT2 and Hypertension.