Arsenic disrupts mitochondrial homeostasis through activation of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3)-transforming growth factor-beta 1 (TGF-β1)/Suppressors of Mothers Against Decapentaplegic (SMAD) signaling pathway, which promotes renal inflammation and fibrosis. This evidence concerns the gene TGFB1 and inflammatory response.