USP37 and colon adenocarcinoma: Figure 2H provides a detailed overview of the types, locations, and frequencies of USP37 genetic alterations. Of the 152 identified genetic variations, “Missense” mutations were the most prevalent, particularly the A491V/X491_splice mutation in the UCH domain. The X491_splice mutations, found in cancers such as GBM and LUSC led to a splice mutation at position 491 of the USP37 protein. Additionally, A491V mutations were identified in UCEC and COAD, resulting in a missense mutation at the same position within the USP37 gene (Figure 2I).