Animals exposed to ELS exhibita long-term increase in hypothalamic CRH mRNA levels and a reduced plasmacorticosterone response [56], and MS exacerbates HPA axis hyperactivity andendocrine pancreatic dysfunction under chronic social defeat stress [57].Alternatively, hyperactivity of the HPA axis may induce a detrimental effect ofMS on behavior following MS, changes in microbiota composition, and activation ofneuroimmune responses [58]. This evidence concerns the gene CRH and myeloid sarcoma.