It has been reported thatmethylation-specific oxytocin receptor genes in the hippocampus may play animportant role in the susceptibility to depression induced by early life stressand that the 5-HT/NE/DA triple reuptake inhibitor LPM570065 may reduce depressionsusceptibility by reversing methylation of the oxytocin receptor gene [77]. This evidence concerns the gene OXTR and depressive disorder.