MTOR and major depressive disorder: Recent studies have also found that Morinda officinalisoligosaccharides upregulate Mfn2 expression to activate thePI3K/Akt/mTOR pathway-mediated mitochondrialautophagy, thereby clearing damaged mitochondria in astrocytes and treating ananimal model of hypertension with depression [66].Salvia miltiorrhiza is one of the commonly used herbs in TCM and hasattracted increasing interest in many medical areas [67].