CRP and obesity due to melanocortin 4 receptor deficiency: This indicates that CRP serves as a morereliable mediator in the association between obesity and depressive symptoms,particularly in males (CRP: PM, 57%; ACME = 0.72 × 10-2 [95% CI =0.39 × 10-2, 1.03 × 10-2], p< 0.001 inmales; CRP: PM, 16%; ACME = 0.50 × 10-2 [95% CI = 0.21 ×10-3, 1.02 × 10-2], p = 0.046 in females).