However, after adjusting for confounding markers such as age, sex, race,alcohol consumption, smoking status, education level, marital status, exerciselevel, and presence of a comorbidity, the association between obesity and NLR wasno longer significant (NLR: β = 0.001737, 95% CI = –0.0089–0.0123,p = 0.748, Cohen’s d = 0.10; CRP: β = 0.922152, 95% CI =0.8911–0.9532, p< 0.01, Partial η2 = 0.05). This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.