CXCL8 and schizophrenia: Otherstudies have also reported similar gender-related effects on cytokine levels inpatients with schizophrenia, possibly due to the influence of menstrual cyclesand sex hormones on cytokine concentrations in women [34, 35, 36], or it could beattributed to the differences in male and female genes, such as Femaleindividuals carrying the homozygous T allele of IL-8 gene rs1126647 polymorphism exhibit an increased susceptibility to paranoid schizophrenia [37].