Most studies have consistently demonstrated that GR function is compromised inmajor depression, with reduced GR-mediated feedback in the HPA axis [36].According to several studies, GR agonists induce acute antidepressant effects.Dexamethasone, a synthetic glucocorticoid, has been administered in combinationwith sertraline and fluoxetine for four days [38] or without dexamethasonetreatment, a single intravenous injection of cortisol rapidly enhances depressivesymptom improvement in patients with depression [39]. Here, NR3C1 is linked to depressive disorder.