In this context, systemic inflammatory markers, such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have emerged as potential indicators of cancer prognosis and metastatic potential across a wide range of malignancies.5These markers reflect our systemic inflammatory response, which, when dysregulated, may contribute to tumor progression and metastasis. The gene discussed is CRP; the disease is cancer.