The results indicated that neutrophil (p = 0.01), monocyte (p = 0.033), LDH (p < 0.001), ESR (p < 0.001), CRP (p < 0.001), and NLR (p = 0.012) have a statistically significant correlation with the incidence of metastasis in osteosarcoma patients (Table 2). This evidence concerns the gene CRP and osteosarcoma.