Relative to noncarriers with middle PRS, having a high PRS increased the odds of PD 37‐fold for dual carriers (OR = 37.38 [18.46, 75.66]), 22‐fold for LRRK2 p.G2019S carriers (OR = 21.78 [18.24, 26.01]), fivefold for GBA1 p.N409S carriers (OR = 4.99 [4.26, 5.84]), and doubled for noncarriers (OR = 2.04 [1.99, 2.10]; Figure 2C; Table S7). This evidence concerns the gene LRRK2 and Parkinson disease.