These secreted molecules, including interleukins (e.g., IL‐6, IL‐8), chemokines (e.g., CCL2, CXCL10), matrix metalloproteinases (MMPs), and growth factors (e.g., VEGF), exert both local and systemic effects on immune surveillance, contributing to immune dysfunction in aged melanoma microenvironments [74]. This evidence concerns the gene IL6 and melanoma.