These secreted molecules, including interleukins (e.g., IL‐6, IL‐8), chemokines (e.g., CCL2, CXCL10), matrix metalloproteinases (MMPs), and growth factors (e.g., VEGF), exert both local and systemic effects on immune surveillance, contributing to immune dysfunction in aged melanoma microenvironments [74]. The gene discussed is CCL2; the disease is melanoma.