EHMT2 and substance dependence: Also, we showed that either viral-mediated NAc G9a knockdown or a systemically administered G9a inhibitor reduced stress-potentiated alcohol drinking by the kappa-opioid agonist U50,488.<h4>Methods</h4>Here, we tested whether NAc G9a knockdown reduces escalated alcohol drinking in a mouse model of combined dependence plus forced swim stress (CIE + FSS) in male mice.