However, no changes in the transcription of Il-17a, as well as Ifn-γ, Il-4 and Il-10 genes were detected in CD4-positive splenocytes of intestinal Dicer1-deleted AD mice, suggesting that there are other molecular signaling pathways than IL-17a inhibition mediating the Aβ-reducing effects. The gene discussed is IL17A; the disease is Alzheimer disease.