As a gene recently discovered to be involved in human retinal disease, we investigated AGBL5 function in a convenient and well-characterised human retinal pigmented epithelial cell line, in order to expand the understanding of the role of AGBL5, validate molecular insights obtained from studies of the Ccp5−/− mouse model in a human model, and provide a useful and easy to manipulate model with which to test the molecular effect of potential therapeutics. Here, AGBL5 is linked to Abnormal retinal morphology.