PXN and cancer: Others have reported that in fibroblasts or epithelial-like cancer cells (Dong et al, 2009; Noh et al, 2021; Sathe et al, 2016; Sen et al, 2012; Sen et al, 2010), paxillin’s nuclear localization is regulated by serine phosphorylation of its nuclear export LD motif and/or nuclear-localizing LIM domain (Deakin and Turner, 2008; Dong et al, 2009; Ma and Hammes, 2018).