BRCA1 and neoplasm: GPVs were detected in seven HR-related genes: BRCA2, BRCA1, RAD51D, ATM, BRIP1, PALB2, and RAD51C. Among patients classified as on-tumor, only 14.3% (1/7) of males were aged ≤64 years, compared to 92.3% (12/13) of females (p < 0.001, Fisher’s exact test) (Fig. 5A).