Our findings on the relationship between T2D polygenic scores and age at diagnosis are consistent with smaller studies in HNF1A-MODY17,18.The absence of interaction with T1D polygenic risk aligns with the current understanding that T1D variants primarily affect autoimmune pathways rather than transcriptional networks disrupted in HNF-MODY24. This evidence concerns the gene HNF1A and type 2 diabetes mellitus.