STAT3 and cancer: Furthermore, our result is in agreement with former findings that identified a nephron-protective effect of nifuroxazide in diabetic kidney, through its effective inhibition of STAT-3 activation, and also with other former studies conducted on various types of cancer, which reported the efficacy of nifuroxazide to inhibit cancer growth and to counteract metastasis via inhibition of STAT-3 phosphorylation [39–42].