Subsequently in 2018, Churchman et al., identified heterozygous germline IKZF1 variants co-segregating with disease in the members of a family characterized by autosomal dominant predisposition to B-ALL, B-lymphopenia and/or hypogammaglobulinemia and found a 0.9% prevalence of germline IKZF1 variants in a large cohort of presumed sporadic B-ALL cases. This evidence concerns the gene IKZF1 and precursor B-cell acute lymphoblastic leukemia.