ETV6 and Thrombocytopenia: A recent study assessing the functional effects of ETV6 variants using CD34+ cell-derived megakaryocytes transduced with lentiviral particles encoding mutant ETV6 revealed disrupted expression of genes related to platelet biogenesis and cytoskeletal dynamics, such as CDC42 and RHOA, which supports the completely penetrant thrombocytopenia phenotype observed in these patients [51].