A splicing variant of REST in which a 50 bp box was inserted between exons 3 and 4 led to the introduction of a frameshift and stop codon and the production of a truncated protein with only 340 amino acids,56 which was identified in seven (15.6%) of the 45 SCLC samples (Supplementary Fig. 9d, e). Here, REST is linked to small cell lung carcinoma.