Compared with patients of Caucasian ancestry with SCLC,2–4 Chinese patients presented a slightly lower TP53 mutation rate (Fisher’s exact test, P = 0.2), a significantly lower RB1 mutation rate (Fisher’s exact test, P = 0.05; Supplementary Fig. 18), and significantly higher mutation rates in 17 genes (Supplementary Fig. 18). The gene discussed is TP53; the disease is small cell lung carcinoma.