HNF4A and cancer: Hepatocyte nuclear factor 4 alpha (HNF4A) is a newly emerging signature for neuroendocrine carcinomas, particularly gastrointestinal neuroendocrine carcinoma.32 However, the expression of HNF4A was relatively low in cancer cells according to our scRNA-seq data (Supplementary Fig. 5a) and bulk RNA-seq data (Supplementary Fig. 5b).