REST and small cell lung carcinoma: However, studies have shown that during lung development, Notch signaling induces a neuroendocrine-to-nonneuroendocrine switch by blocking precursor differentiation into neuroendocrine cell, and promoting neuroendocrine-to-club cell transformation through RE1-silencing transcription factor (REST) and YAP1.43,44 Hence, these results suggest that SCLC may still develop from a common progenitor cell.