ALPK1 and retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome: While our mice thus more closely mimic the heterozygous presentation of human ROSAH syndrome patients, the more muted effects of a single copy of human ALPK1[T237M] may have translated to serum chemokine production at levels below the limits of detection for our ELISAs.