ALPK1 and retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome: A significant increase in the frequency of GFAP positivity was detected in the nerve fiber layer of ROSAH model mice as compared to ALPK1-KI controls, and the administration of DF-003 (3 mg/kg) suppressed 49% of the increase in astrocyte activity (Fig. 5).