ROSAH patients also exhibit inflammatory features such as non-infectious low-grade fevers, arthralgia, headaches, and persistently elevated levels of serum inflammatory cytokines including tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), and IL-1β3. This evidence concerns the gene IL6 and retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and migraine headache syndrome.