Aged SIRT2 KO mice exhibit compromised muscle function, cognitive function, stem cell exhaustion, metabolic disorder, and susceptibility to severe COVID‐19 (Figures 1,S2) (He et al. 2020; Barthez et al. 2025; Luo et al. 2019; Tang et al. 2017; Y. Zhang et al. 2023; Fourcade et al. 2017; Ma et al. 2022), consistent with the notion that aging‐associated inflammation is linked to aging‐associated conditions and diseases. The gene discussed is SIRT2; the disease is Other metabolic disease.