OLFM4 and Barrett esophagus: Our analysis placed gastric chief cells close to foveolar cells-1 originating from gastric fundus and BE tissue, leading to the group of intestinal metaplasia cells, which consists of cells with goblet cell differentiation markers, but also expressing the intestinal stem cell marker OLFM4. The trajectory closely connected foveolar cells-1 with intestinal metaplasia cells, suggesting foveolar cells-1 as the cell of origin for BE (Figure 4B).