For instance, B-ALL patients with various BCR/ABL-related genetic abnormalities, such as BCR/ABL P190 positive with deletion of multiple exon heterozygosity, BCR/ABL positive with IKZF1 large fragments missing, and BCR/ABL-like individuals, were employed to collect SERS data of CSF samples (Figure S18). The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.