We generated iPSC-derived organoids from a DEE-13 patient, patient 1 (P1), with a gain-of-function variant (p.R1872>L) in the SCN8A gene, associated with refractory seizures and intellectual disability.7 Organoids from P1 (Mut) and a matched CRISPR-corrected control line (iCtrl) were directed toward cortical, hippocampal, or ganglionic eminence (GE) fates. Here, SCN8A is linked to Intellectual disability.