These findings substantially expand our understanding of DEE-13 beyond mouse models, which have primarily focused on the seizure activities attributed to the dysfunction of ExNs in the forebrain, without investigation of hippocampal dynamics.36,46 The aberrant phase coupling seen in the assembloid models underscores the potential of these SCN8A variants to disrupt hippocampal function and suggests that hippocampal-dependent cognitive deficits may occur without cortical seizure-induced pathology. The gene discussed is SCN8A; the disease is Cognitive impairment.