Within the Tip5 interval, cathepsin Z (Ctsz; alternative names: cathepsin X, cathepsin P) and zinc finger protein 831 (Zfp831) were significantly induced in the lungs of genetically heterogeneous Diversity Outbred (DO) mice exhibiting progressive TB, characterized by elevated pulmonary Mtb burden and inflammation [52]. The gene discussed is ZNF831; the disease is tuberculosis.