Subsequent WIKIPathways enrichment analysis revealed that several miRNAs were significantly enriched in pathways associated with breast cancer (hsa-miR-22-3p, hsa-miR-181a-5p and hsa-miR-152-3p), DNA damage response (hsa-miR-152-3p and has-miR-148a-3p) and PI3K-Akt signaling (hsa-miR-152-3p), indicating their roles as upstream/downstream effectors in 4-NP-induced breast cancer. Here, PIK3CA is linked to breast cancer.