AMPH and fungal infectious disease: AMPH-B, which is a fungicidal drug that interacts with ergosterol molecules and forms a membrane-spanning pore, is approved for the treatment of fungal infections at doses ranging from 2.5 to 5 mg kg−1 (≥6 mg kg−1 for cryptococcosis), with a single dose of 2.5 mg kg−1 producing a maximum plasma concentration of 17.2 μg ml−1 [19].