Given that patients with PC are resistant to chemoimmunotherapy, we established 2 human PC stable cell lines (AsPC-1-R and MIA PaCa-2-R) that are resistant to gemcitabine and inactivate CD8+ T cells (Supplemental Figure 1, A–F; supplemental material available online with this article; https://doi.org/10.1172/JCI195970DS1). The gene discussed is CD8A; the disease is pachyonychia congenita.