For example, chemotactic factors such as CXCL13 and growth factors driving myelopoiesis such as CSF1 were tightly interconnected with a central positioning of IL-6 and IL-8, both cytokines signifying innate, specifically myeloid immune activation with a known prominent role in atherosclerosis in network analyses. The gene discussed is CXCL8; the disease is atherosclerosis.