While V5-p8 immunoprecipitated p52ΔC, which likely exists as free, unfolded protein, no other TFIIH subunits were coimmunoprecipitated, indicating that p8 may not be incorporated into the TFIIH complex in the cells from the patient with XP-J (Figure 3A). The gene discussed is GTF2H4; the disease is xeroderma pigmentosum.