HMOX1 and septic shock: In patients with septic shock, calcitriol increased the expression of IL-10 (2.6-fold, adjusted P < 0.05) (Figure 6B), whereas in those without septic shock, calcitriol increased the expression of HMOX1 (1.3-fold, adjusted P < 0.05) (Figure 6C and Supplemental Table 6).