However, cardiomyocyte-specific Rac1 knockin mice (Rac1cKI/cKI; Myh6-Cre) exhibited significantly exacerbated cardiac hypertrophy in response to AngII (Figure 3, A–C), indicating hypersensitivity to AngII-induced cardiac hypertrophy in the absence of Rac1 S-palmitoylation. Here, RAC1 is linked to cardiac hypertrophy.