To examine the role of Rac1 S-palmitoylation in a model of pathologic cardiac hypertrophy and failure driven by hypertrophic signaling in cardiomyocytes and independent of changes in blood pressure, we crossed Rac1cKI mice with transgenic mice overexpressing AT1R in cardiomyocytes (TgAT1R mice) (10). Here, AGTR1 is linked to cardiac hypertrophy.