To gain insights into whether TLR9/BCR coactivation causes similar remodeling in primary B cells and in MCD DLBCL, we cross-compared proteomes from αIgM/CpG-stimulated primary B cells or the tumor-derived MCD DLBCL HBL1 cell line with resting primary B cells. The gene discussed is TLR9; the disease is diffuse large B-cell lymphoma.