Furthermore, previous work from members of our group and others has shown spatial variability in the progression of tau pathology, which may not be present in the entorhinal cortex in all cases.44,45 Additionally, our study did not take into account non-AD neuropathological conditions, such as vascular disease, limbic-predominant age-related TDP-43 encephalopathy neuropathologic change,46 or Lewy body disease,47 that may have added to atrophy in an additive or synergistic fashion.48,49. Here, MAPT is linked to Alzheimer disease.