Previous work from members of our group has shown that increasing Aβ+ duration is associated with faster cognitive decline, a greater risk of cognitive impairment, and the spread of NFT accumulation from early Braak stage regions to later ones.20,34,41 Our study complements these findings by showing that harboring Aβ plaques for longer is also associated with accelerated volume loss, even after controlling for tau. Here, MAPT is linked to Mental deterioration.