The S100A8/A9-upregulated gene set matched to “pathways in cancer” in the pathway analysis using the KEGG database and included c-Jun (blue circle) and a series of well-established cancer-relevant genes (green circle), such as cell cycle enhancers (CCND1 (cyclin D1), CCNA2 (cyclin A2), and SKP2), FGF signaling (FGF7), transcription factors (ETS1 and STAT3), and Wnt–beta-catenin signaling (WNT5A) (Fig. 5B, right panel). Here, JUN is linked to cancer.