In addition, abundant extracellular S100A8/A9 can recruit more S100A8/A9-producing cells into the tumor site, where they continue to secrete S100A8/A9 along with inflammatory cytokines, chemokines, and growth factors, thus forming a sustained positive feed-forward loop that efficiently promotes cancer cell proliferation and invasion. The gene discussed is IGKV1D-22; the disease is neoplasm.