In our prior investigations, we demonstrated that ETS translocation variant 4 (ETV4), also referred to as polyoma enhancer activator 3 (PEA3), located downstream of MCAM, serves as a critical transcription factor (TF) that drives melanoma metastasis through robust upregulation of matrix metalloproteinase-25 (MMP25). The gene discussed is ETV4; the disease is melanoma.