Immune alterations also include increased CD4 +/CD8 + and IL-17 + γδ T cells, and elevated expression of immunosuppressive (IDO1, IL-10, PD-L1) and oncogenic (AKT1, STAT3, CXCR4) genes with key roles in tumor progression and immune evasion [73, 74, 78]. This evidence concerns the gene STAT3 and neoplasm.