Genes associated with immunosuppression (e.g., IDO1, IL-10, CD274, ARG1, and CD80) and oncogenesis (e.g., CXCR4, SDF-1, AKT1, and STAT3) were significantly upregulated in ex vivo isolated blood myeloid and plasmacytoid dendritic cells of patients with chronic periodontitis, while SOCS3 and SOCS1 were downregulated [74]. This evidence concerns the gene AKT1 and chronic periodontitis.