P.g. also manipulates inflammatory signaling in SCC-25 cells by activating NF-κB and MAPK pathways, driving tumor-associated inflammation and metastasis via upregulation of CCL20, TNFAIP6, CXCL8, TNFAIP3, TRAF5, CYP1A1, and NOD2 gene expression [101]. The gene discussed is NOD2; the disease is neoplasm.