Porphyromonas intermedia infection promoted growth of SCC-7 cells injected into the buccal submucosa, leading to angiogenesis, muscle invasion, lymph node metastasis, and elevated expression of Ki-67, VEGF-A, IL-6, IL-17, and ISG15. The gene discussed is IL6; the disease is metastatic malignant neoplasm in the lymph nodes.