H2AX and cancer: Genes and proteins evaluated in animal studies were associated with inflammation and immune response (Foxp3, IL1β, IL18, IL6, IL-17, NF-κB, NLRP3, TNF-α); regulation of the inflammasome and apoptosis (ASC, Caspase-1, Foxo3, NLRP3); immune cell activity and macrophage polarization (CD11b, CD206, CD3, CD4, CD45, CD8, F4/80, PD-1); cell proliferation and DNA damage response (ATR, CHK1, Cyclin D1, γ-H2AX, Ki-67, RAD51); and signaling pathways involved in inflammation, genomic stability, and cancer progression (IL6, STAT).