Tregs, tumor-associated macrophages, and myeloid-derived suppressor cells inhibit T-cell activity via PD-1/PD-L1 and CTLA-4/CD80/86 pathways, while OSCC cells release VEGF, TGFβ, IL-6, and IL-10 to suppress immunity [7]. The gene discussed is TGFB1; the disease is neoplasm.