Similar non-significant interactions were observed in the pooled cohort study, although to a lesser extent: for the probability of VWF occurrence, the χ2 values were 10.6 (df 9) for the interaction A(8) × age (P = 0.300) and 5.08 (df 3) for the interaction A(8) × metabolic disorders (P = 0.167). The gene discussed is VWF; the disease is metabolic disease.